TARDBP and amyotrophic lateral sclerosis: However, in late 2006, Aria [56] and Neumann [57] independently reported that the heavily ubiquitinated inclusions in the brains of FTLD-TDP and amyloid lateral sclerosis (ALS) patients were predominantly composed of abnormally hyperphosphorylated and ubiquitinated TDP-43 protein, indicating a possible common pathogenic mechanism.