Domschke and partners [234] found that the rs7103411, Val66Met (rs6265) and rs7124442 BDNF polymorphisms are related with worse response to antidepressant treatment over 6 weeks in major depression, particularly in the melancholic depression (for rs7103411 and Val66Met) and anxious depression (for rs7124442) clinical subtypes. Here, BDNF is linked to major depressive disorder.