Given the importance of p53-, RB- and PP2A-dependent protective barriers against tumorigenesis and their role in regulating cell differentiation and self-renewal [40], aberrant reactivation of EMT inducers might profoundly affect the multistep nature of tumorigenesis by increasing cell plasticity and leapfrogging the mutation bottleneck toward tumor progression. The gene discussed is RB1; the disease is neoplasm.