To examine the contribution of the RAI1/Rai1 gene to the metabolic phenotypes of PTLS, we compared the metabolic profile of TgRai1 animals [35] that overexpress Rai1 but do not have copy number change of most of the surrounding genomic regions to that of Dp(11)17/+ mice. The gene discussed is RAI1; the disease is Potocki-Lupski syndrome.