TLR4 and serum lipopolysaccharide activity: LPS forms a complex with LPS binding protein and CD14 which in turn delivers LPS to MD2 and LPS-MD2 complex activates through TLR4 resulting in dimerization of TLR4 [3] and initiate the signaling process for production of cytokines and other critical molecules needed for hyper-inflammation associated with endotoxemia/sepsis [12].