TNFRSF18 and neoplasm: A separate issue deals with the relationship of GITR and tumors, well reviewed by Placke et al. [50] and Schaer et al. [44], who describe how GITR importance has grown up since it was found to be involved in tumor rejection, in studies that used anti-GITR antibodies or GITR recombinant proteins, as also described below in this paper.