A more general role of PPARγ in regulation of cell differentiation and proliferation has been proposed on the basis that PPARγ agonists thiazolidinediones may prevent formation of neoplastic lesions in animal tumor models, exert growth-inhibitory effects in addition to reinduction of differentiation in several human cancers and in tumors induce changes in the cell cycle with growth arrest and apoptosis. Here, PPARG is linked to neoplasm.