Given that the PAX8-PPARγ rearrangement was found in a higher proportion of FTC (30%) and in one case of FTA with a thick capsule and immunohistochemical profile characteristic of thyroid cancer, the authors suggested it may represent a pre-invasive (in situ) FTC in which the invasion was overlooked by the pathologist. The gene discussed is PAX8; the disease is thyroid cancer, nonmedullary, 2.