Whereas statistical analyses did not prove that IFIH1 was the primary associated locus, support for this hypothesis came from massive resequencing of IFIH1 in T1DM patients and controls which revealed four rare variants (rs35667974/Ile923Val, rs35337543/IVS8+1, rs35744605/Glu627X, rs35732034/IVS14+1) associated with the disease, independently both from each other and from rs1990760 [197]. The gene discussed is IFIH1; the disease is type 1 diabetes mellitus.