Double-positive (DP) cells (CD117+ and Stro-1+) from 3 mouse osteosarcoma cell lines were also more tumorigenic with 7 of 7 and 4 of 6 mice growing tumor when injected with 200 DP cells with two of the cell lines and 3 of 5 mice growing tumor with 2,000 DP cells injected from a third mouse osteosarcoma cell line. Here, KIT is linked to neoplasm.