A five-gene panel was found that optimally discriminates early PD from controls based on stepwise multivariate logistic regression analysis of seven genes that were found significantly altered in sporadic PD SN tissue[11](ALDH1A1PSMC4SKP1AHSPA8, c-src Tryosine Kinase CSK, huntingtin interacting protein 2/ubiquitin-conjugating enzyme E2K HIP2 and Egl nine homolog 1 EGLN1). This evidence concerns the gene UBE2K and Parkinson disease.