For example, VEGF plays an important role in the vascularization of the expanding adipose tissue in development or obesity [56]; GRB-14 inhibits insulin action [57,58]; TFAP2B affects adipokine secretion and adipocyte insulin sensitivity [59,60] and TBX15 differentiation and lipid accumulation [61]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.