FOLH1 and neoplasm: The tetrameric biotin-streptavidin complex containing twobiotinylated strands of the A9  aptamer and two biotinylated siRNAmolecules targeted against mRNAs of the lamin A/C or GADPH genes ( Fig. 11A ) was used to deliversiRNAs into PSMA-positive tumor cells [74].These complexes could penetrate into cells without the use of transfectants.