These conjugates could bind to LNCaP cells distributed over themodel tissue (3D collagen matrix) with high levels of efficiency and specificity.“Double” constructs consisting of the anti-PSMA-RNA-aptamerA10 and the peptide aptamer against PSMA-negative cells immobilizedon a gold electrode were used for the electrochemical detection of two types ofprostate cancer cells: those that contained PSMA on their surface (PSMA-positive)and those that did not contain the protein (PSMA-negative) [91]. The gene discussed is FOLH1; the disease is cancer.