The results obtained attest to the fact that the PKC and CCNB1 genes are the most efficient targets for gene-targeted action on SK-N-MCneuroblastoma cells and CCNB1  breast cancer cells, respectively.In SK-N-MC cells, the antiproliferative effect of silencing theCCNB1 and  PKC  genes is considerably higherthan that conditioned by siHer ( Table1 ). The gene discussed is CCNB1; the disease is breast carcinoma.