The genomic typing of 18  allelic groups of the HLA- DRB1  gene and the following single-nucleotide polymorphisms (SNPs) 49A>G of the CTLA4 gene; –509C>T ofthe TGFB1  gene; –590C>T of IL4 gene; –403G>A of the RANTES  gene; –1562C>T of the MMP9  gene; 372C>T of the TIMP1  gene; as well as of the deletion-insertion polymorphism CCR5  (w→d) (“wild type” → deletion of 32  bp), was carried out for Russian MS patients and their healthy parents, followed by the analysis of genetic predisposition to MS using the TDT and AFBAC methods. Here, CTLA4 is linked to myeloid sarcoma.