CYP1A1 and reproductive system disorder: Our previous associative studies of xenobiotic detoxification genes have shown that women with reproductive system diseases (mainly myomas and chronic cystic mastitis) carrying the 606G, 4889G alleles of the CYP1A1 gene have an increased frequency of somatic mutations at the T-cell receptor (TCR) locus in peripheral blood lymphocytes (phentoype CD 3- CD 4+ ).