In the case of hepatoma HA–1,the intramuscular administration of either RNase A or DNase I led to a decrease in the liverweight relatively to the control, with a therapeutic efficacy of 30–42% for RNase A and40–53% for DNase I. A histological analysis of the lungs and liver has shown that bothenzymes similarly destroy tumor cells and increase the number of necroses and apoptoses inmetastatic foci. The gene discussed is RNASE1; the disease is hepatocellular carcinoma.