EVPL and chronic myelogenous leukemia, BCR-ABL1 positive: This leads to suggest that the cause of CML is the imbalance between stem cells self-renewal and myeloid progenitors maturation, rather than Ph+ cells proliferation under the action of p210 bcr/ abl , as follows from many other studies [4-7,10-12, 15, 16, 19, 24-29, 31].