Eight new asthma susceptibility genes have been discovered by positional cloning: ADAM33 (desintegrin and melloproteinase-33), DPP10 (dipeptidyl peptidase-10), PHF11 (plant homeodomain finger protein-11), GPRA (G protein-coupled receptor for asthma), HLA-G (histocompatibility antigen), CYFIP2 (cytoplasmic fragile X mental retardation-interacting protein 2), IRAKM (interleukin 1 receptor-associated kinase), and OPN3 (opsin-3) [25, 26]. The gene discussed is ADAM33; the disease is asthma.