APOE and coronary artery disorder: For carriers of the E4 allele, the risk of CAD development is 20% higher than those without it, and the cholesterol levels in low-density lipoproteins increase in the following direction (in terms of the presence of the APOE allele): E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, E4/E4.