Due to tumor suppressors Discs large(Dlg) and Lethal (2) giant larvae (Lgl) localized in the cortex, the apical Par complex provides the basal localization of the RN A-binding Staufen protein, the transcription Prospero (Pros) factor, the Numb protein which associates with plasma membrane, and the adaptor proteins Miranda (Mira) and Partner of Numb (Pon) [27, 28]. Here, NUMB is linked to neoplasm.