C24:1 sulfatide was included in this study since it forms a stable complex with CD1d, can assemble into tetrameric complexes [9] and treatment of B10.PL, C5BL/6 and SJL/J mice with C24:1 but not sulfatide with shorter fatty acyl side chains reverses ongoing experimental allergic encephalomyelitis (EAE) [Maricic et al., in preparation], a mouse model of multiple sclerosis [5]. This evidence concerns the gene CD1D and multiple sclerosis.