CD1D and type 1 diabetes mellitus: Using CD1d-deficient mice that lack the expression of CD1d and presence of iNKT cells, we observed a 90–95% incidence of T1D in NOD.Scid recipients of lymphocytes from donor NOD.CD1d−/− mice treated with C24:0 sulfatide or vehicle (Fig. 2), in support of the reports that splenocytes from B6.CD1d−/− mice are unable to function as APCs [30] or present sulfatides to human type II NKT cells [32].