INS and Glucose intolerance: Furthermore, fructose, the main sweetener of westernized diet, is deemed to be a contributing factor to these epidemic disorders [7], where exposure of liver to such large quantities of fructose and fats leads to rapid stimulation of lipogenesis with the accumulation of triglycerides (TGs) that contribute, in turn, to reduced insulin sensitivity and hepatic insulin resistance/glucose intolerance [8].