STX2 and hemolytic-uremic syndrome: It has also been suggested that the increased virulence of the E. coli O104:H4 outbreak strain could in part be related to the EAEC bacterial host genome, which has evolved adaptations for attachment and survival in the human intestine and that these adaptations have facilitated the systemic absorption of Stx2, which in turn increased the risk of developing HUS [3], [45].