CYP24A1 and cancer: When cancer was subdivided according to location (breast, lung, colorectal and prostate), rs6013897 at the CYP24A1 gene showed a significant relation with breast cancer (P<0.05) where the minor homozygote, which was the one with the lowest serum 25(OH)D level, had an 86% higher risk of developing breast cancer than the major and reference homozygote (Figure 1).