VEGFA and endometriosis: Furthermore, treatment with ISO-1 significantly inhibited the expression of vascular endothelial cell growth factor (VEGF), a major angiogenic factor, (P<0.01) (Figure 6D) and that of COX2 and IL8 which play a role in endometriosis-associated inflammation, angiogenesis and tissue remodeling [28], [44], [45], [46], [47] (P<0.001 and P<0.05, respectively) (Figure 6, E and F).