In addition, patients who were positive for human leukocyte antigen A2 (HLA-A2) received a multipeptide tumor antigen vaccine that was based on peptides derived from human telomerase reverse transcriptase (hTERT) and survivin, 2 “universal” tumor antigens that are often overexpressed in myeloma and may have prognostic relevance [330–332]. This evidence concerns the gene BIRC5 and neoplasm.