CYBB and hepatocellular carcinoma: Furthermore, NADPH oxidase inhibition by VAS inhibitors could be detected in various native, i.e. non-overexpressing, cells expressing different NOX isoforms, including PMA-stimulated human granulocytes (expressing NOX2) [72] and DMSO-differentiated HL60 cells (mainly expressing NOX2) [59], several liver carcinoma cell lines [73], oxLDL-treated human umbilical vein endothelial cells (HUVEC) [74], and PDGF-stimulated primary murine vascular smooth muscle cells [70].