PML and neoplasm: PML codifies for a phosphoprotein localized in nuclear bodies involved in recognition and/or processing of DNA breaks and able to arrest cell cycle in G1 by recruiting TP53 and MRE11A [36]; RUVBL1 encodes a highly conserved ATP-dependent DNA helicase that plays a role in apoptosis and DNA repair [37]; TXNIP acts as a tumor suppressor, as its transfection induces cell-cycle arrest in G0/G1 and is downregulated in human tumors [38] and RASSF1 is a tumor suppressor that blocks cell cycle progression by inhibiting CCND1 accumulation.