We chose to study three molecular mechanisms (chromosomal, methylation and sequence abnormalities) by which IGF2 expression could have been reduced in 4 women selected to have a similar phenotype to our published case report [18] who had severe intrauterine growth restriction, precocious pubarche, short stature and insulin resistance, and was found to have a balanced translocation affecting her IGF2 gene regulation. Here, IGF2 is linked to Insulin resistance.