Aberrant imprinting of the IGF2/H19 locus on chromosome 11p15.5 has a crucial role in Beckwith-Wiedemann syndrome (BWS, OMIM #130650) [1], Silver-Russell syndrome (SRS, OMIM#180860) [2,3] and several human cancers [4,5]. This evidence concerns the gene IGF2 and Beckwith-Wiedemann syndrome.