CD40LG and type 2 diabetes mellitus: Increased urinary IgM excretion and IgG2/IgG4 ratio in macroalbuminuric type 2 diabetic patients compared to type 1 diabetic patients suggests that the proteinuria in type 2 diabetes is due to size-selectivity defects, while charge selectivity defects account for the proteinuria in type 1 diabetes [116].