Thus, although abnormalities in somatotroph axis activity have been hypothesized to account for the low IGF-I levels in the psoriatic patients, with a possible primary or secondary effect of these disturbances on the psoriasis process modulation [33], the more likely association of low IGF-I with the common inflammatory pathways of both metabolic syndrome or psoriasis has not been considered as far. This evidence concerns the gene IGF1 and psoriasis.