Sánchez-Moya et al. report that, among one hundred and forty-four patients with moderate-to-severe psoriasis treated with anti-TNF-α agents, a total of 42 (29%) patients were diagnosed with LTBI based on a positive tuberculin skin test (TST) or re-TST, and/or signs of past TB in the chest X-ray. The gene discussed is TNF; the disease is psoriasis.