In laryngeal carcinoma, it has been reported that hypomethylation is linked to the polymorphism of the genes regulating DNA methylation including methionine synthase (MTR) and 5, 10-methylenetetrahydrofolate dehydrogenase, 5, 10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase (MTHFD1), and methylenetetrahydrofolate reductase (MTHFR). Here, MTR is linked to laryngeal carcinoma.