In head and neck cancer, aberrant promoter methylation has been found in a wide variety of genes including p14ARF, p15, p15INK4B, p16, p16INK4A, ATM, DCC, DAPK, MINT1, MINT2, MINT27, MINT31, RARbeta, CDH1, cyclin A1, cytoglobin, RASSF1A, LHX6, MLH1, MGMT, and CDKN2A [26–35]. The gene discussed is CDKN2B; the disease is head and neck cancer.