The authors found multiple significant variables related to the development of complications: over 65 years of age, male sex, smoking and alcoholism, location of the tumor in the hypopharynx, reconstruction of the hypopharynx, advanced stage of the primary tumor, comorbidities (diabetes, hypertension, and arterial sclerosis), low albumin and hemoglobin, and previous radiation therapy on the site to be reconstructed. The gene discussed is ALB; the disease is alcohol dependence.