In a multivariate analysis with adjustment for size, nodal status, ER, pathological grade, HER2, Ch17CEP duplication, Ki67, Ch17CEP*TREAT (treatment by marker interaction for Ch17CEP and treatment), tumour CIN%, TREAT (treatment) and tumour CIN%*TREAT showed only nodal status (for RFS and OS), and ER and high tumour CIN% (for OS but not RFS) to be statistically significant. Here, MKI67 is linked to neoplasm.