BCL2 and chronic myelogenous leukemia, BCR-ABL1 positive: Most notably, several recent studies highlight an emerging role for Lyn kinase overexpression and activation in the development of imatinib-resistance in CML [9-12], and activated Lyn results in elevated levels of the anti-apoptotic protein Bcl-2, which protects CML cells from imatinib-mediated cell lethality [13].