In GBM, we have found that SULF2 protein is expressed in adult and pediatric tumors (Figure 3) and, using knockdown and transgenic approaches, we have demonstrated ablation of SULF2 results in decreased activity of several RTKs, including PDGFR-alpha, decreased tumor cell proliferation, and prolonged survival in vivo[40]. The gene discussed is PDGFRA; the disease is glioblastoma.