In GBM, we have found that SULF2 protein is expressed in adult and pediatric tumors (Figure 3) and, using knockdown and transgenic approaches, we have demonstrated ablation of SULF2 results in decreased activity of several RTKs, including PDGFR-alpha, decreased tumor cell proliferation, and prolonged survival in vivo[40]. This evidence concerns the gene SULF2 and neoplasm.