IGHE and allergic asthma: Although OVA-specific IgE in plasma were comparable in WT and knockout mice, enhanced inflammatory cell recruitment from circulation and cytokine release in lung and BALf, accompanied by higher airway resistance, as well as enhanced pause in response to methacholine, indicate a regulatory role for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in the development of allergic asthma.