CCL2 and asthma: Also, while T cell-mediated functions like Th2 cytokine secretion, and proliferation to OVA were upregulated synchronous with the overall robustness of the asthma phenotype, macrophage upregulation in functions such as proliferation, mixed lymphocyte reaction, and MCP-1-directed chemotaxis, but downregulation of respiratory burst response, indicate a forking in their signaling pathways.