In multivariate analysis, we showed that the heterozygous and homozygous variant genotype of VEGF 936C/T conferred an improved OS compared with the homozygous wild-type genotype ... Although this is the first study to evaluate VEGF SNPs in esophageal cancer, two prior gastric cancer studies reported conflicting results ... There are limitations to this study. The gene discussed is VEGFA; the disease is gastric cancer.