Importantly, plasma cell tumor samples from p80HT mice (n = 5) showed even higher levels of cyclin D1, IL-10 and survivin than p80HT B cells (Figure 3C), suggesting that plasma cells or their precursor B cells with high-level expression of these genes were preferentially selected in the development of plasma cell tumors in p80HT mice. This evidence concerns the gene BIRC5 and neoplasm.