Upregulation of cyclin D is a major oncogenic event in MM pathogenesis [27], and in p80HT B cells, the expression of both cyclin D1 and cyclin D2 was significantly increased (cyclin D1, +2.47 fold, P = 0.038; cyclin D2, +2.58 fold, P = 0.009). Here, CCND2 is linked to Miyoshi myopathy.