PRRT2 and colon carcinoma: Carriero et al reported that binding of uPA to uPAR regulates integrins in a PKC-dependent manner in MDA-MB-231 and MCF-7 breast carcinoma cell lines (21), and Rigot et al reported that integrin engagement by PKCs was required for the migration of HT29-D4 colon carcinoma cells (6).