SH3BP2 and cherubism: Based on these observations Lietman and coworkers examined whether wild-type SH3BP2 increased NFAT translocation, and activation and TRAP activation in RAW 264.7 cells and whether SH3BP2 mutants found in cherubism patients further increased NFAT and TRAP activation to induce the osteoclastic bone lesions of cherubism [53,66].