NF1 and Noonan syndrome: Interestingly, bilateral mandibular cherubism-like lesions and giant cell lesions in the mandible and in long bones have been described in neurofibromatosis patients [32,33], and are associated with mutations in the neurofibromin gene, NF1. NF1 is known as a regulator of the RAS pathway and mutations in NF1 are associated with neurofibromatosis and Noonan syndrome [34,35].