On the other hand, the topological nodes that remained hidden to the direct transcriptomic and proteomic analyses include a much larger number of molecules, many of which also belong to important cancer associated families such as SMAD (SMAD1, 2, 3, 4, 7), FOX (FOXA2, C1, C2, M1), GATA (GATA1, 2, 3, 6), and MMP (MMP7, 8, 10, 13, 16, 20). Here, SMAD1 is linked to cancer.