On the other hand, the topological nodes that remained hidden to the direct transcriptomic and proteomic analyses include a much larger number of molecules, many of which also belong to important cancer associated families such as SMAD (SMAD1, 2, 3, 4, 7), FOX (FOXA2, C1, C2, M1), GATA (GATA1, 2, 3, 6), and MMP (MMP7, 8, 10, 13, 16, 20). The gene discussed is FOXA2; the disease is cancer.