Subsequently, it binds to transcription factors and drives the uncontrolled expression of target genes implicated in cell proliferation, transformation, and tumor progression, such as Myc, matrix metalloproteinase 7, Axin-2, the cell adhesion molecule L1-CAM, the metastasis gene S100A4, and others [33,43,44]. The gene discussed is AXIN2; the disease is neoplasm.