We have shown that the secreted extracellular matrix protein, TGFBI (transforming growth factor beta induced), is a critical component of the ovarian cancer tumor microenvironment that sensitizes cells to paclitaxel-induced cell death by stabilizing microtubules via integrin-mediated activation of focal adhesion kinase (FAK) and the Rho family GTPase RhoA [1]. This evidence concerns the gene TGFBI and ovarian cancer.