For resting CD4 T cells, in which the cytoskeletal actin is relatively static [27], the Jas IC50 dosage for HIV-1 infection was 60 nM, whereas for transformed Rev-CEM indicator cells [109,110], the Jas IC50 for HIV-1 infection was 250–500 nM [29]. The gene discussed is CD4; the disease is HIV-1 infection.