The safety and efficacy of ipilimumab and vemurafenib combination therapy is currently being assessed in a prospective, multicenter phase I/II trial (NCT01400451) of patients with BRAF V600 mutation-positive metastatic melanoma to determine whether additional benefits are possible with combination therapy compared with the use of either agent alone or their sequential use; however, results from this study are not due until 2015. The gene discussed is BRAF; the disease is metastatic melanoma.