Indeed, the most significant findings suggesting that Zn2+ regulation may be such a factor in AD, is the reported coordination, stabilization, and synaptic targeting of Aβ oligomers by Zn2+[25,26,43] along with increased Zn2+ levels and decreased ZnT3 mRNA and protein expression in the AD brain [27-30,32]. The gene discussed is SLC30A3; the disease is Alzheimer disease.