MAPK8 and neoplasm: Emmprin can promote tumor cell invasion via activation of urokinase-type plasminogen activator, nuclear factor kappa B (NF-κB) and c-Jun N-terminal kinase (JNK) and stimulate tumor angiogenesis via vascular endothelial cell growth factor (VEGF), and is thus implicated in other aspects of tumor progression, such as tumor survival and angiogenesis [20,21].