DGCR8 and ovarian cancer: DROSHA (RNASEN) is RNAse III enzyme mediating processing of pri-miRNAs into pre-miRNAs with DGCR8. The significance of aberrant expression levels of DROSHA as a potential prognostic factor has been substantiated in several studies on esophageal cancer [34], cervical neoplastic progression [35], ovarian cancer [36], and neuroblastoma [37] .