DROSHA (RNASEN) is RNAse III enzyme mediating processing of pri-miRNAs into pre-miRNAs with DGCR8. The significance of aberrant expression levels of DROSHA as a potential prognostic factor has been substantiated in several studies on esophageal cancer [34], cervical neoplastic progression [35], ovarian cancer [36], and neuroblastoma [37] . The gene discussed is DROSHA; the disease is esophageal cancer.