SPHK2 and multiple sclerosis: Fingolimod, a recently introduced therapeutic for multiple sclerosis (Chun and Brinkmann,2011), readily crosses the blood-brain barrier (Meno-Tetang et al.,2006) and is phosphorylated to FTY720-phosphate (FTY720-P) predominantly by endogenous sphingosine kinase-2 (SphK-2) (Billich et al.,2003).