There has been some precedence for extracellular PPIA-mediated ERK1/2 phosphorylation in several cell lines that include monocytes, macrophages, neuronal, and lung cancer epithelial cells [13,14,22,23,39] and deregulation of ERK1/2 signaling is implicated in many diseases including cancer [40]. This evidence concerns the gene MAPK3 and lung carcinoma.